Elephant Hawk logo Elephant Hawk ← Chrysalis library Start Tools Log In Context Brief

🇪🇺 Europe Deep-Dive — The Mature Medtech-Export Cohort

Aggregate of EU + UK + Switzerland + Nordics in the US FDA database. Europe is the most-established foreign cohort entering the US — orthopedics, dental, imaging, and surgical incumbents that own US market share new entrants must compete with or partner alongside.
Generated: 2026-06-06 23:31.
Free edition · Published by Elephant Hawk — elephanthawk.com/tools

Contents

  1. TL;DR
  2. Strategic Synthesis
  3. Country Breakdown
  4. Top European Sponsors
  5. Specialty Focus
  6. Top Product Codes
  7. Predicate Citations
  8. Safety & Recall Profile

TL;DR

5y EU+UK+CH clearances
3,209
1,186 unique sponsors
Last 12mo
544
33.3% of all foreign clearances
Countries
26
production geographies
Mature portfolios (≥10 clearances)
45
deep US market presence

Synthesis

The European cohort represents the mature global medtech establishment, sitting comfortably between China's fragmented cottage industry (3,317 clearances scattered across hundreds of small manufacturers) and India's nascent export base (151 clearances from a narrow handful of firms). With 3,209 clearances from 1,186 unique sponsors across 26 countries over five years, Europe demonstrates both scale and concentration—the 45 sponsors holding 10+ clearances signal established regulatory competence and diversified product portfolios, while the trailing-twelve-month pace of 544 new clearances confirms sustained commercial momentum. Europe commands 33.3% of all foreign US clearances, a share that reflects decades of accumulated know-how in navigating FDA pathways. The production centers are unambiguous: Germany leads with 679 clearances, followed by France (409) and Switzerland (400), forming a central European spine of precision manufacturing, clinical validation infrastructure, and regulatory expertise that has no peer outside the United States.

The top-five sponsor roster reads like a orthopedic-surgical hall of fame with strategic imaging adjacencies. Medacta International S.A. (Switzerland, 100 clearances) and Depuy Ireland UC (Ireland, 47) anchor the orthopedic implant segment—hips, knees, trauma fixation—while Philips Medical Systems Nederland B.V. (Netherlands, 44) and Brainlab AG (Germany, 41) represent advanced imaging, surgical navigation, and radiotherapy planning. Medos International SARL (Switzerland, 32) rounds out the top tier with spine and neurosurgical implants. The broader cohort includes dental specialists like Straumann and Geistlich, surgical visualization leaders like Karl Storz, and orthopedic platforms such as Lima Corporate. This specialty distribution reveals Europe's export strength: high-margin capital equipment (imaging, navigation, endoscopy), precision implants requiring tight tolerances and biocompatibility pedigrees, and niche surgical consumables where clinical validation and surgeon preference entrench market positions.

Country Breakdown

Which European countries are the actual medtech-export production centers? Germany, Ireland (heavy MNC manufacturing presence), Italy (ortho), Netherlands (Philips ecosystem), UK, Switzerland (dental + medtech), and the Nordics dominate.

Country5y clearancesUnique sponsorsLast 12mo
DE 679 232 115
FR 409 170 78
CH 400 92 70
GB 358 157 45
IT 344 128 51
NL 172 56 37
IE 161 55 25
SE 142 64 23
ES 137 54 23
DK 107 46 16
BE 79 31 13
FI 62 27 11
AT 47 30 10
SI 19 7 2
PL 18 9 4
NO 13 7 3
IS 12 2 4
HU 11 9 1
PT 10 4 6
GR 7 3 2
SK 6 3 1
LU 5 2 1
BG 4 2 1
LT 4 3 2
CZ 2 1 0
LV 1 1 0

Top European Sponsors by 5y Activity

SponsorCountry5y clearancesLast 12mo Distinct codesMost recent
Medacta International S.A. CH 100 17 32 2026-05-05
Depuy Ireland UC IE 47 4 16 2026-05-15
Philips Medical Systems Nederland B.V. NL 44 9 11 2026-03-17
Brainlab AG DE 41 6 10 2025-10-16
Medos International SARL CH 32 2 11 2026-03-27
Institut Straumann AG CH 27 4 4 2026-05-07
Lima Corporate S.P.A. IT 26 3 10 2026-01-22
Karl Storz SE & CO. KG DE 22 9 15 2026-03-02
Siemens Healthcare GmbH DE 21 6 8 2026-04-10
GE Medical Systems SCS FR 21 3 5 2026-03-24
Waldemar Link GmbH & Co. KG DE 20 1 9 2025-11-05
Terrats Medical SL ES 19 4 2 2026-04-16
Ambu A/S DK 19 2 8 2026-04-30
Materialise NV BE 18 4 6 2026-03-12
Sorin Group Italia S.R.L. IT 17 4 8 2026-01-30
Voco GmbH DE 17 4 10 2026-05-01
Implantcast GmbH DE 16 3 7 2026-04-24
Geistlich Pharma AG CH 15 7 5 2026-03-19
Medartis AG CH 15 2 2 2026-04-17
Stryker Leibinger GmbH & Co KG DE 15 3 6 2026-03-12
Qura S.R.L IT 15 0 4 2024-09-12
Elekta Solutions AB SE 14 4 5 2026-02-19
Nobel Biocare AB SE 14 2 4 2026-02-18
El.En S.P.A. IT 14 3 6 2026-04-02
Quanta System Spa IT 14 1 1 2025-06-06
Orthofix Srl IT 13 2 6 2026-05-19
Light Tree Ventures Europe B.V. NL 13 2 5 2026-05-12
Ziehm Imaging GmbH DE 13 0 2 2025-03-17
Icotec AG CH 13 1 8 2025-11-12
Brainomix Limited GB 12 1 4 2025-08-26
Fotona D.O.O. SI 12 0 4 2025-03-27
Carl Zeiss Meditec, AG DE 12 0 8 2025-01-10
Siemens Healthcare Diagnostics Products GmbH DE 12 0 9 2024-10-10
Spectrum Medical , Ltd. GB 12 5 9 2026-03-12
Elos Medtech Pinol A/S DK 11 2 1 2026-05-20
Olympus Winter & Ibe GmbH DE 11 2 7 2026-05-21
Newclip Technics FR 11 2 2 2026-03-11
S.M.A.I.O FR 10 4 2 2026-04-03
Stryker Corporation DE 10 4 5 2026-02-03
Erbe Elektromedizin GmbH DE 10 4 3 2026-04-22

Specialty Focus

Specialty5y clearancesUnique sponsorsLast 12mo
Radiology 632 245 113
Orthopedic 530 120 78
General, Plastic Surgery 304 140 42
Dental 300 131 48
Cardiovascular 292 127 65
Neurology 250 114 50
Gastroenterology, Urology 178 100 31
General Hospital 105 63 15
Anesthesiology 102 53 20
Obstetrics/Gynecology 85 50 8
Physical Medicine 71 47 11
Ear, Nose, Throat 62 33 8
Microbiology 62 28 17
Ophthalmic 57 30 8
Unknown 53 34 14

Top European Product Codes

CodeDeviceClassSpecialty EU clearancesEU sponsors
LLZ System, Image Processing, Radiological II Radiology 151 86
QIH Automated Radiological Image Processing Software II Radiology 83 55
GEX Powered Laser Surgical Instrument II General, Plastic Surgery 83 33
NHA Abutment, Implant, Dental, Endosseous II Dental 78 16
OLO Orthopedic Stereotaxic Instrument II Neurology 62 22
HRS Plate, Fixation, Bone II Orthopedic 52 16
DZE Implant, Endosseous, Root-Form II Dental 48 25
NKB Thoracolumbosacral Pedicle Screw System II Orthopedic 43 19
GEI Electrosurgical, Cutting & Coagulation & Accessories II General, Plastic Surgery 41 24
IYE Accelerator, Linear, Medical II Radiology 40 15
OWB Interventional Fluoroscopic X-Ray System II Radiology 38 15
LZO Prosthesis, Hip, Semi-Constrained, Metal/Ceramic/Polymer, Cemented Or Non-Porous, Uncemented II Orthopedic 37 9
LNH System, Nuclear Magnetic Resonance Imaging II Radiology 34 14
PHX Shoulder Prosthesis, Reverse Configuration II Orthopedic 34 10
DQK Computer, Diagnostic, Programmable II Cardiovascular 29 16
MAX Intervertebral Fusion Device With Bone Graft, Lumbar II Orthopedic 28 19
MUJ System, Planning, Radiation Therapy Treatment II Radiology 28 13
JWH Prosthesis, Knee, Patellofemorotibial, Semi-Constrained, Cemented, Polymer/Metal/Polymer II Orthopedic 27 10
JAK System, X-Ray, Tomography, Computed II Radiology 26 10
MBI Fastener, Fixation, Nondegradable, Soft Tissue II Orthopedic 24 6

Where European Firms Cite Predicates

The 510(k) Summary PDFs reveal which prior devices each European sponsor cited as substantial-equivalence basis. 1,865 of 1,976 parsed European filings have at least one citation; 6,484 citations total. Read this as: when European medtech firms enter the US, whose existing US clearances do they ride?

Country of cited predicates

Predicate's HQ countryDistinct EU filers citingTotal citations
US 257 335
DE 243 298
CH 168 267
FR 158 194
IT 93 120
GB 94 118
CN 33 37
KR 19 21
IL 19 20
ES 10 11
BR 8 11
SE 10 10
DK 8 8
CA 7 7
JP 7 7
Distinct from China and India: European firms cite a far more diverse predicate base — they cite each other (EU-to-EU), they cite US incumbents heavily, and they cite Japan / Korea where the device is in those specialties. There is no "single anchor" predicate ecosystem in Europe like there is for China (Mindray) — European medtech is genuinely federated.

Top 30 sponsors cited as predicates by European filers

Sponsor (cited)HQ country Cited by EU filersTotal citations Codes touched
Medacta International S.A. CH 59 96 HSX, JDR, JWH, KRO, KRR, LLZ, LPH, LZO
Brainlab AG DE 33 38 HAW, IYE, LLZ, MUJ, OLO, QIH, QQC
Institut Straumann AG CH 20 33 DZE, NHA
Lima Corporate S.P.A. IT 18 30 JWH, LPH, MBF, MBH, PHX
Medos International SARL CH 17 21 HRX, KRA, MAX, MBI, NKB, NKG, OLO
Siemens Medical Solutions USA, Inc. US 13 33 IYN, JAK, KPS, LLZ, LNH, MUJ, OUO, QIH
Siemens Healthcare GmbH DE 12 14 LLZ, LNH, OEB, QDQ, QIH
Qura S.R.L IT 12 13 DTR, DTZ, DWF, KFM
Medacta Inernational SA CH 12 12 PHX, PQC, SBF
Waldemar Link GmbH & Co. KG DE 11 18 JWH, LPH, LZO, MBH, PHX
Quanta System Spa IT 11 13 GEX
Stryker Leibinger GmbH & Co KG DE 10 14 DZL, JEY, OLO
Stryker GmbH US 10 12 ERL, GEI, HRS, HSB, KTT, KWS, MEH
GE Medical Systems SCS FR 10 11 JAK, KPS, LLZ, OWB
Icotec AG CH 9 16 KWQ, MQP, NKB, ODP, PML
Spineart CH 9 12 NKB, ODP, OLO
S.M.A.I.O FR 8 13 LLZ, NKB
Implantcast GmbH DE 8 12 HSD, KWT, LZO, MEH
Ziehm Imaging GmbH DE 8 9 JAA, OWB
Medartis AG CH 7 14 HRS, HWC
Bonebridge AG CH 7 10 HRS
Geistlich Pharma AG CH 7 9 MQV, NPL, NPM
Philips Medical Systems Dmc GmbH DE 6 9 JAA, KPR, MQB
Medentika GmbH DE 6 8 NHA
Carl Zeiss Meditec, AG DE 6 7 HQC, NFJ, QFX
Medtronic US 6 6 DQY, NKB, NKG
Avicenna.Ai FR 6 6 POK, QAS
Ischemaview, Inc. US 6 6 LLZ, POK, QAS
Heidelberg Engineering GmbH DE 6 6 OBO
Brainomix Limited GB 5 17 JAK, LLZ, POK, QAS

Safety & Recall Profile

Recall enforcement actions against European-located firms. Total: 1,426 recalls · 63 Class I · 270 unique firms. Class I recall density signals operational stress — these are the firms whose US position may be vulnerable to a lower-cost manufacturer's entry.

FirmCountryTotal recallsClass IMost recent
PHILIPS MEDICAL SYSTEMS NEDERLAND B.V. Netherlands 183 20 2026-04-28
GET TESTED INTERNATIONAL AB Sweden 92 0 2025-11-03
RAYSEARCH LABORATORIES AB Sweden 83 0 2025-11-28
Waldemar Link GmbH & Co. KG (Mfg Site) Germany 61 0 2026-02-11
SEDECAL SA Spain 53 0 2025-06-10
Randox Laboratories Ltd. Ireland 43 0 2024-06-07
Inpeco S.A. Switzerland 30 0 2025-10-30
DAYE (ANNE'S DAY LTD) United Kingdom 29 0 2025-02-17
Stryker GmbH Switzerland 26 0 2025-05-28
Radiometer Medical ApS Denmark 22 0 2025-03-21
Corin Ltd United Kingdom 21 0 2023-10-13
GE Healthcare Finland Oy Finland 19 9 2025-09-26

European Clinical Trials

Studies with at least one EU/UK/Swiss/Nordic location, last 5y.

NCT Title Sponsor Status Phase Started N Results
NCT07608679 Estimation of the Prevalence of Microcirculatory Dysfunction in Uremic Cardiopathy Among Dialysis Patients Centre Hospitalier Departemental Vendee Not Yet Recruiting NA 2027-09-01 30
NCT05798754 Efficacy of CompuFlo® Technology in Thoracic Epidural Space Identification General and Maternity Hospital of Athens Elena Venizelou Not Yet Recruiting NA 2027-04-01 276
NCT07614373 Virtual Reality-based Mindfulness Training for Mental Health After Stroke Nicolas Nicastro Not Yet Recruiting NA 2027-04-01 48
NCT07629674 Visual Stimulation Through Video Therapy to Enhance Lower Limb Motor Recovery After Stroke Centre Hospitalier Universitaire de Saint Etienne Not Yet Recruiting NA 2027-02-01 12
NCT07620522 Observational Study of RHINOSEDAL in Acute Nasal Obstruction Laboratoires Elerte Not Yet Recruiting 2026-10-15 126
NCT07622472 Remote Monitoring and Optimization of Heart Failure Therapy Zoll Medical Corporation Not Yet Recruiting NA 2026-10-01 800
NCT07628179 SENECA - Smart Therapies for Chronic Pain Aurimod GmbH Not Yet Recruiting NA 2026-09-17 44
NCT07613944 Ultrasound Assessment of Tongue Characteristics in Adolescents With Obesity and Obstructive Sleep Disorders Vrije Universiteit Brussel Not Yet Recruiting NA 2026-09-01 80
NCT06547138 Pilot Study on the Effectiveness and Safety of OPTILENE® SILVER MESH ELASTIC in Prevention of Surgical Site Infection (SSI) and Incisional Hernia (IH) Aesculap AG Not Yet Recruiting 2026-09-01 110
NCT07595341 Effects of Inspiratory Training on Respiratory Function in Swimming Universidad Rey Juan Carlos Enrolling By Invitation NA 2026-09-01 34
NCT07575750 Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) in Aromatase Inhibitor-induced Arthralgia (AIA) Institut Cancerologie de l'Ouest Not Yet Recruiting NA 2026-09-01 60
NCT07592637 Lung Disease and FLNA Mutations University Hospital, Lille Not Yet Recruiting NA 2026-09-01 70
NCT07559643 The OAT Trail: The Obesity Anti-Coagulation Thromboprophylaxis Trial. University College Dublin Not Yet Recruiting NA 2026-08-01 180
NCT07606963 Triton 1.5 Robotic System for Diagnostic Colonoscopy Neptune Medical Not Yet Recruiting NA 2026-08-01 40
NCT07603531 Assessment of the Efficacy of the Dynamic Decongestive System in the Maintenance Phase of Lower Limb Lymphedema Jean-Paul Belgrado Not Yet Recruiting NA 2026-07-01 98
NCT07609511 Magnet System Gastric Outlet Obstruction Study GT Metabolic Solutions, Inc. Not Yet Recruiting NA 2026-07-01 10
NCT07130136 Post-market Evaluation of the Transition From the Baha Connect System to the Osia System in Adult Bone Conduction Implant Recipients Cochlear Not Yet Recruiting NA 2026-07-01 20
NCT07593261 MRI-Guided Adaptive Radiotherapy for Limited Peritoneal Metastases (MARACAS Trial). Fondazione Policlinico Universitario Agostino Gemelli IRCCS Not Yet Recruiting PHASE2 2026-07-01 34
NCT07628075 Long-Axial Field of View (LAFOV) [18F]FDG PET/CT Imaging in Large Vessel Vasculitis (LVV): Protocol Optimisation Study. Imperial College London Not Yet Recruiting NA 2026-07-01 18
NCT07616726 Exploration and Characterization Ofintratumoral Electrophysiological Heterogeneity in Gliomas Using Magnetoencephalography Hospices Civils de Lyon Not Yet Recruiting NA 2026-07-01 60
NCT07588399 STRATegy SUccesS in High-Risk PCI With Impella CP: Evaluation of Hemodynamic Protection in Complex PCI Rayyan Hemetsberger Not Yet Recruiting NA 2026-07-01 50
NCT07627022 Impact of a Reminder App on Physical Activity During Radiation Therapy for Lung Cancer University Hospital Schleswig-Holstein Not Yet Recruiting NA 2026-07-01 32
NCT07593638 Plasma Exchange Half-dose and Extracorporeal Detoxification for ACLF Unidade Local de Saude do Nordeste Not Yet Recruiting NA 2026-07-01 240
NCT07622615 Assessment of the Efficacy of the Dynamic Decongestive System in the Intensive Phase of Lower Limb Lymphedema Jean-Paul Belgrado Not Yet Recruiting NA 2026-07-01 110
NCT07341126 Use of a Novel Camera to Check the Bowel After Polyp or Tumour Removal University of Edinburgh Not Yet Recruiting 2026-07-01 30
NCT07619872 KONECT RESILIA Aortic Valved Conduit (AVC) Real-world Study Assessing Safety and Performance Edwards Lifesciences Not Yet Recruiting 2026-06-30 250
NCT07430540 Optimising Colorectal Cancer Patient Pathways University of Edinburgh Not Yet Recruiting NA 2026-06-30 1,000
NCT07618897 Efficacy of Sub-laminar and/or Interspinous Tethers to Prevent Proximal Junctional Kyphosis After Surgical Correction of Adult Spinal Deformity Hospices Civils de Lyon Not Yet Recruiting NA 2026-06-22 128
NCT07615023 Clonal Hematopoiesis of Indeterminate Potential and Infarct Severity in ST-Elevation Myocardial Infarction Medical University Innsbruck Not Yet Recruiting 2026-06-20 350
NCT07589023 A Retrospective Review: Outcomes of the REFLECT™ System for Idiopathic Scoliosis Globus Medical Inc Not Yet Recruiting 2026-06-15 100
NCT07544654 DAREON®-NEC-1: A Study in People With Advanced Extrapulmonary Neuroendocrine Cancer to Compare Obrixtamig Plus Carboplatin and Etoposide Treatment With Standard Chemotherapy Boehringer Ingelheim Not Yet Recruiting PHASE3 2026-06-15 390
NCT06458517 Evaluation of Two Methods of Administration of Photobiomodulation in the Context of the Prevention and Treatment of Mucositis Induced by Radiotherapy, During the Treatment of Head and Neck Cancers Centre Paul Strauss Not Yet Recruiting NA 2026-06-15 60
NCT07611526 Investigation of the Individual Fatigue Response During Blood Flow Restriction Training University Hospital, Bonn Not Yet Recruiting NA 2026-06-15 20
NCT07628491 Effect of Finishing Clear Aligner Marginal Termination Design (Supragingival vs Juxtagingival) on Aligner Color Stability After 14 Days of Wear: A Split-Mouth Study George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures Not Yet Recruiting NA 2026-06-15 50
NCT07624929 The Use of Immersive Virtual Reality as a Method of Treating Anxiety and Procedural Pain During Endovenous Laser Ablation (EVLA) of Lower Varicose Veins Under Tumescent Anesthesia Bydgoszcz University of Science and Technology Enrolling By Invitation NA 2026-06-10 100
NCT07628023 Comparison of Cardiac Index Measurement Using Right Ventricular Pressure Curve Analysis and Thermodilution Via a Swan-Ganz IQ™ Catheter. Assistance Publique - Hôpitaux de Paris Not Yet Recruiting 2026-06-10 43
NCT07236463 Labile Iron Removal by Adding the Iron Chelator MEX-CD1 to Dialysate in Sepsis-Associated Acute Kidney Injury Centre Hospitalier Universitaire de Nīmes Recruiting PHASE1 / PHASE2 2026-06-04 14
NCT07600463 UVC in Prevention of Surgical Wound Infection Ville Leinonen Not Yet Recruiting NA 2026-06-04 75
NCT07628959 Pilot Study of Innovative Sleep Quality Analysis Software Compared With Polysomnography Centre Hospitalier Universitaire de Saint Etienne Not Yet Recruiting NA 2026-06-01 33
NCT07602296 The Benefits of Transcranial Photobiomodulation in Lewy Body Disease University Hospital, Strasbourg, France Not Yet Recruiting NA 2026-06-01 40
NCT07628686 EMBRACE - From Vulnerable to Empowered: Implementation and Evaluation of a Multicomponent Program to Tackling Age-related Decline University Fernando Pessoa Not Yet Recruiting NA 2026-06-01 120
NCT07616050 Evaluation of the Impact of Virtual Park on Training Motivation in Adult Patients Marta Mondellini Not Yet Recruiting NA 2026-06-01 70
NCT07622563 Automated Oxygen Control in Preterms on Non-invasive Ventilation King's College Hospital NHS Trust Not Yet Recruiting NA 2026-06-01 76
NCT07467382 GOAT (Gait Observation of Achilles Tendon) Nantes University Hospital Not Yet Recruiting 2026-06-01 60
NCT07603453 Performance of Clinical Metagenomics in Stool and Urine Samples for Unexplained Diseases Diagnostic and Emerging Diseases Surveillance in Immunocompromised Patients Assistance Publique - Hôpitaux de Paris Not Yet Recruiting 2026-06-01 120
NCT07621055 VOLta Medical AI-software in REal-World During AF Ablation Volta Medical Not Yet Recruiting 2026-06-01 150
NCT05865379 Efficacy and Safety of BUFY01 Versus SVS20 in the Treatment of Dry Eye Disease TRB Chemedica International SA Recruiting NA 2026-06-01 80
NCT07600502 Establish Whether Hyperangulated Videolaryngoscopy (HAVL) Can be Used to Facilitate Tracheal Intubation Effectively and Safely in Unselected Adult Patients; Describe the Population in Whom HAVL Fails to Facilitate Tracheal Intubation Successfully, Identifying Any Contributory Characteristics. NHS Lothian Not Yet Recruiting NA 2026-06-01 500
NCT07602309 Tedlar Bag Stability of Volatile Sulfur Compounds for Remote Halitosis Diagnosis University Hospital, Strasbourg, France Not Yet Recruiting NA 2026-06-01 100
NCT07606547 Biomechanical Effects of EMST® on Swallowing Function in Parkinson's Disease University Hospital Muenster Recruiting NA 2026-06-01 30

Publications from European Authors

Papers with European author affiliations, last 5y.

PMID Title Journal Authors Date Why
42207915 · DOI AI-assisted teams outperform AI-led teams but not human-only teams in assessing research reproducibility in quantitative social science. Proceedings of the National Academy of Sciences of the United States of America A Castillo Alvarez G, Abdelhady M, Abdelmoula Y, Aguirre T et al. 2026-06-02 Sponsor
42190020 · DOI Rates of speciation and past extinctions affect food webs on continental scales. Proceedings of the National Academy of Sciences of the United States of America Polly PD 2026-06-02 Sponsor
42201638 · DOI Contemporary Description of Clinical Characteristics and Outcomes in Patients with Hereditary ATTR Amyloidosis: Results from the Multicountry OverTTuRe Study. Cardiology and therapy Alexander KM, Anderson LJ, Bhimjiyani AG, Davis L et al. 2026-06-01 Sponsor
42165362 · DOI Plasminogen Activator Inhibitor-1 is Internalized by Endothelial Cells via A Pinocytosis-Like Mechanism and Evades Degradation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology Ahmetaj G, Eichmann A, Hauschel R, McAdow M et al. 2026-05-31 Sponsor
42208565 · DOI Alzheimer's disease. Lancet (London, England) Dubois B, Escott-Price V, Grinberg LT, Pascoal T et al. 2026-05-30 Sponsor
42208560 · DOI Efficacy and safety of a bodyweight-adjusted higher dose of ocrelizumab in relapsing (MUSETTE) and primary progressive (GAVOTTE) multiple sclerosis: two multicentre, randomised, double-blind, parallel-group phase 3b trials. Lancet (London, England) Bar-Or A, Bonati U, Bonek R, Giovannoni G et al. 2026-05-30 Sponsor
42208561 · DOI Efficacy and safety of ocrelizumab in primary progressive multiple sclerosis, including older patients and those with more advanced disease (ORATORIO-HAND): a multicentre, double-blind, randomised, placebo-controlled, phase 3b study. Lancet (London, England) Airas L, Baldinotti A, Bonati U, Bove R et al. 2026-05-30 Sponsor
41863923 · DOI Binding characteristics and mechanisms underlying the enhanced stability of anthocyanins by proteins screened with molecular docking. Food chemistry He Y, Li B, Li Z, Quintana R et al. 2026-05-30 Sponsor
42208564 · DOI Efficacy and safety of intravenous prasinezumab in individuals with early-stage Parkinson's disease on stable symptomatic monotherapy (PADOVA): a phase 2b, multicentre, randomised, double-blind, placebo-controlled study. Lancet (London, England) Anzures-Cabrera J, Boak L, Bonni A, Brundin P et al. 2026-05-30 Sponsor
41865758 · DOI Efficacy and safety of oral semaglutide 14 mg (flexible dose) in early-stage symptomatic Alzheimer's disease (evoke and evoke+): two phase 3, randomised, placebo-controlled trials. Lancet (London, England) Abschneider RM, Atri A, Cummings JL, Feldman HH et al. 2026-05-30 Sponsor
42208563 · DOI Comparison of [18F]flortaucipir and [18F]MK6240 for the detection of tau pathology in Alzheimer's disease (HEAD): a multicentre, prospective, cross-sectional, within-participant study. Lancet (London, England) Amaral L, Baker S, Bauer-Negrini G, Bellaver B et al. 2026-05-30 Sponsor
42216686 · DOI Multiple-TE Based Blood-Brain-Barrier Water Exchange Time Measurement Using a TE-Resolved 3D TSE Stack-Of-Spirals Readout. Magnetic resonance in medicine Chang Y, Detre JA, Franco LL, Günther M et al. 2026-05-30 Sponsor
42214301 · DOI Thrombectomy stroke centers: Clinical, economic and environmental assessment at the nationwide level. Journal of neuroradiology = Journal de neuroradiologie Arquizan C, Barthe T, Bocquet AL, Cagnazzo F et al. 2026-05-29 Sponsor
42215446 · DOI Differences in how NMDA antagonists modulate negative affective biases in male rats may serve as a predictor of clinical efficacy in major depressive disorder. Translational psychiatry Arban R, Bartlett J, Hengerer B, Hinchcliffe JK et al. 2026-05-29 Sponsor
42215303 · DOI Distinct Longitudinal Patterns of Basal and Squamous Cell Carcinoma in Polycythemia Vera and Essential Thrombocythemia. American journal of hematology Gangat N, Guglielmelli P, Loscocco GG, Pardanani A et al. 2026-05-29 Sponsor
42210772 · DOI Embracing technology to improve peripheral intravenous access and care: A consensus statement from vascular access experts and patients. The journal of vascular access Hadaway L, Hopkins T, Schears G, Spencer TR et al. 2026-05-29 Sponsor
41231614 · DOI Troxerutin is a novel osmotic agent for peritoneal dialysis with protective cardiovascular actions. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Cortés M, Eringa EC, González-Mateo GT, Kane J et al. 2026-05-29 Sponsor
42216082 · DOI Development of a face-validated conceptual model structure for economic evaluation in phenylketonuria, through expert elicitation. Orphanet journal of rare diseases Chakrapani A, Feillet F, Hamazaki T, Hollander S et al. 2026-05-29 Sponsor
42215378 · DOI Four-year survival outcomes with dostarlimab plus chemotherapy in mismatch repair deficient/microsatellite instability-high primary advanced or recurrent endometrial cancer in the RUBY trial. Gynecologic oncology Austin L, Black D, Boere I, Buscema J et al. 2026-05-29 Sponsor
42210696 · DOI Standardized numbering and alignment of the KPC family of β-lactamases. Antimicrobial agents and chemotherapy Amicosante G, Arias C, Bethel CR, Bonomo RA et al. 2026-05-29 Sponsor
42213273 · DOI An LC-MS untargeted metabolomic comparison between three blood microsampling devices, whole blood, and plasma. Metabolomics : Official journal of the Metabolomic Society Auriola S, Avella D, Avgerinou G, Hanhineva K et al. 2026-05-29 Sponsor
42216253 · DOI Flight of the dragons: a global review of migration in Odonata. Biological reviews of the Cambridge Philosophical Society Chapman JW, Hayward A, Hedlund JSU, Menz M 2026-05-29 Sponsor
42209750 · DOI Pediatric fatal head and neck injury in a 9-year medical examiner case series: autopsy findings and cervical spine dissection techniques. International journal of legal medicine Campobasso CP, Gitto L, Introna F, Macorano E 2026-05-29 Sponsor
42215259 · DOI Response to: "Methodological limitations and conflicts of interest in spinal cord stimulation research impair trustworthiness". Regional anesthesia and pain medicine Duarte RV, Eldabe S, Goudman L, Hunter CW et al. 2026-05-29 Sponsor
42214435 · DOI Current Practices in Hyperglycemia Management in Neonatal Encephalopathy: A THiNE (Treatment of Hyperglycemia in Neonatal Encephalopathy) Consortium Study. American journal of perinatology Chavez-Valdez R, Cohen SS, Dizon MLV, Law JB et al. 2026-05-29 Sponsor
42213847 · DOI International multisite implementation of distributed cell-free protein biomanufacturing to advance health and research equity. Science advances Arce A, Athale CA, Ayi K, Bayat P et al. 2026-05-29 Sponsor
42210649 · DOI Resilience to HPV vaccine safety scares in seven countries. Journal of global health Almeida P, Batmunkh T, Brewer NT, Ellingson MK et al. 2026-05-29 Sponsor
42209817 · DOI Post-hoc analysis of adverse events during the EPOCH trial: reconsidering dosimetry. European journal of nuclear medicine and molecular imaging Boucher E, Fowers K, Garin E, Harris W et al. 2026-05-29 Sponsor
42215632 · DOI Insights from the LysoNeo prospective cohort study to improve newborn screening of lysosomal diseases. Communications medicine Apetrei A, Arion A, Ausseil J, Bach N et al. 2026-05-29 Sponsor
42202003 · DOI A miniaturized implantable electrochemical platform for continuous monitoring of metabolites in deep tissue. Science advances Cho S, Ciatti JL, Hintermueller D, Huang YT et al. 2026-05-29 Sponsor
42172306 · DOI Mitochondrial complex I activity promotes antigen cross-presentation in dendritic cells. Science immunology Belinchón-García A, Chandel NS, Dunphy G, Enamorado M et al. 2026-05-29 Sponsor
42215959 · DOI Physicians and relatives facing end-of-life decisions in intensive care: ethical insights from a comparison of French and American models. BMC medical ethics Giabicani M, Mamzer MF, Robinson EM, Rubin J et al. 2026-05-29 Sponsor
42214415 · DOI Modeling variable interactions using Bayesian networks to identify direct predictors of radiation-induced optic neuropathy after proton therapy. Physics in medicine and biology Chamseddine I, Lebhertz D, Paganetti H, Pham TN et al. 2026-05-29 Sponsor
42212939 · DOI Developing Predictive Models by Sharing Predictions - An Investigation of a Federated Learning Approach for ADMET Predictions. Journal of medicinal chemistry Bhhatarai B, Broccatelli F, Desai P, DiFranzo A et al. 2026-05-29 Sponsor
42212672 · DOI Efficacy and Safety of Anselamimab in Immunoglobulin Light Chain Amyloidosis: Results From the Randomized CARES Trials. Journal of clinical oncology : official journal of the American Society of Clinical Oncology Bhutani D, Bianchi G, Carpinteiro A, Catini J et al. 2026-05-29 Sponsor
42213348 · DOI Safety evaluation of a novel progesterone vaginal ring (PVR) for luteal phase support: SARA trial. Drug delivery and translational research Foster ED, Grover SA, Heiser PW, Park JK et al. 2026-05-29 Sponsor
42215335 · DOI Unmet Treatment Need and Challenges Associated with Comparative Evidence Generation in BCG-unresponsive Non-muscle-invasive Bladder Cancer: An Expert Consensus. European urology oncology Babjuk M, Bridge D, Delattre DD, Gontero P et al. 2026-05-29 Sponsor
42215489 · DOI An open multi-center MEG-EEG dataset for studying conscious visual perception. Scientific data Bonacchi N, Brown T, Das D, Ferrante O et al. 2026-05-29 Sponsor
42215983 · DOI Predictive ability of novel glycovariant biomarkers of CA125 and CA15-3 up to three years prior to ovarian cancer diagnosis: a population-based case-control study. Journal of ovarian research Afrin Ruma S, Idahl A, Israelsson P, Jain S et al. 2026-05-29 Sponsor
42215656 · DOI Author Correction: The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2. Nature cancer Abad M, Aguilera M, Al-Shahrour F, Arribas J et al. 2026-05-29 Sponsor

Pre-prints from European Authors

Pre-prints whose corresponding-author institution is in EU / UK / Switzerland / Nordics. Leading-edge signal.

DOI / Platform Title Corresponding author + institution Category Posted Peer-reviewed?
medrxiv
10.64898/2026.05.28.26353952
The Multimodal Anonymizer: a fully local multi-agent AI system for medical data deidentification Julian Madrid
Charite Universitaetsmedizin Berlin, Institute for Artificial Intelligence in Medicine, Invalidenstrasse 120, 10115 Ber…
health informatics 2026-06-05 Published
medrxiv
10.64898/2026.06.03.26354630
Integrating patient movement and pathogen genomics to support hospital infection prevention with PathoPath: a method development study Yu Wan
David Price Evans Global Health and Infectious Diseases Research Group, University of Liverpool, Liverpool, United Kingd…
infectious diseases 2026-06-05 Published
medrxiv v2
10.64898/2026.06.04.26354648
A single-nucleus transcriptomic atlas of human basal ganglia during development forwarding diagnosis and therapy of pediatric movement disorders Markus Schuelke
Charite - University Medical Center, Berlin, Germany
neurology 2026-06-05 Published
medrxiv v2
10.64898/2026.04.14.26350838
The Cartilage Thickness score (CTh-Score) Captures High-resolution Cartilage Thickness Patterns Associated with Osteoarthritis Onset, Progression, and Knee Replacement: Data from the Osteoarthritis Initiative Paul Margain
Lausanne University Hospital and University of Lausanne (CHUV-UNIL), Department of Orthopedic Surgery and Traumatology, …
radiology and imaging 2026-06-05 Published
biorxiv v3
10.64898/2025.12.15.694388
Symbiosis through lysis: host-triggered prophage induction drives probiotic function in Lactiplantibacillus plantarum Renata C. Matos
Institut de Genomique Fonctionnelle de Lyon, Ecole Normale Superieure de Lyon, CNRS UMR 5242, Universite Claude Bernard …
microbiology 2026-06-05 Published
biorxiv
10.64898/2026.06.02.729637
Rational engineering of sdAb-based CAR T cells targeting BCMA enhances antitumor efficacy and persistence in Multiple Myeloma Juan Roberto Rodriguez-Madoz
Hemato-Oncology Program, Cima Universidad de Navarra. IdiSNA. Pamplona, Spain.
bioengineering 2026-06-05 Published
biorxiv v2
10.1101/2025.11.07.687260
A functional amyloid matrix underpins the PDIM-architected corded superstructure of the Mycobacterium tuberculosis biofilm Richard Haindl
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria
microbiology 2026-06-05 Published
biorxiv
10.64898/2026.06.05.730402
Minimal effective dose of telacebec administered orally in a murine model of leprosy Alexandra Aubry
Sorbonne Universite, CNRS, INSERM, Centre d'Immunologie et des Maladies Infectieuses, CIMI, APHP, Paris, France
microbiology 2026-06-05 Published
biorxiv
10.64898/2026.06.04.730152
Microbial community profiles of the snake cloaca in the presence and absence of Chlamydiota Gilbert Greub
Institute of Microbiology, University Hospital Center and University of Lausanne, Lausanne, Switzerland
microbiology 2026-06-05 Published
medrxiv
10.64898/2026.06.04.26354901
Concurrent tDCS-fMRI: Impact of the current-induced magnetic fields on the measured BOLD signal Axel Thielscher
Section for Magnetic Resonance, DTU Health Tech, Technical University of Denmark, Kgs Lyngby, Denmark
radiology and imaging 2026-06-05 Published
medrxiv v3
10.1101/2025.10.10.25337763
Clearance of asymptomatic genital HPV infections in young adult women is shaped by host immune response Nicolas Tessandier
MIVEGEC, CNRS, IRD, Université de Montpellier, France
infectious diseases 2026-06-04 Published
biorxiv v4
10.64898/2026.01.21.699709
Comparing DNA Extraction Protocols for Freshwater Prokaryotic Communities: Impacts on Yield and Microbial Profiling Arthur Szylit
Universite Littoral Cote d Opale, UMR CNRS 8187 LOG, Wimereux, France
microbiology 2026-06-04 Published
medrxiv
10.64898/2026.06.04.26354648
A single-nucleus transcriptomic atlas of human basal ganglia during development forwarding diagnosis and therapy of pediatric movement disorders Markus Schuelke
Charite - University Medical Center, Berlin, Germany
nephrology 2026-06-04 Published
medrxiv
10.64898/2026.06.03.26354821
Pooled testing for SARS-CoV-2 surveillance in schools: real-world evaluation of transmission control, testing resources, and educational disruption Vittoria Colizza
Sorbonne Université, INSERM, Pierre Louis Institute of Epidemiology and Public Health, Paris, France
infectious diseases 2026-06-04 Published
medrxiv
10.64898/2026.06.03.26354793
Bayesian networks to estimate prognosis in vascular cognitive impairment and small vessel disease: integrated analyses of interdependent contributors to multiple outcomes L. Malin Overmars
Department of Neurology and Neurosurgery, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Neth…
neurology 2026-06-04 Published
medrxiv v3
10.1101/2024.11.11.24317109
Reproducibility of electroencephalography alpha band biomarkers for diagnosis of major depressive disorder Alexandra Reichenbach
Center for Machine Learning, Heilbronn University, Heilbronn, Germany
psychiatry and clinical psychology 2026-06-04 Published
medrxiv
10.64898/2026.05.27.26352937
VNtyper 2 enables open-access short-read genotyping of MUC1 VNTR variants in ADTKD at high-speed Bernt Popp
Berlin Institute of Health at Charité, Universitätsmedizin Berlin, Center of Functional Genomics, Berlin, Germany
nephrology 2026-06-03 Published
medrxiv
10.64898/2026.06.02.26354233
Prognostic performance of an AI-based recurrence risk model in clinically low-risk HR+/HER2- early breast cancer Pieter J. Westenend
Laboratory of Pathology, Dordrecht, Netherlands
oncology 2026-06-03 Published
medrxiv
10.64898/2026.06.02.26354705
Automated histopathological measurements of the tumor micro-environment predict distant metastasis after stage I/II Melanoma: discovery and validation in the population-based Dutch Early-Stage Melanoma (D-ESMEL) study Antien Mooyaart
Department of Pathology & Clinical Bioinformatics, Erasmus MC Rotterdam, the Netherlands
dermatology 2026-06-03 Published
medrxiv
10.64898/2026.06.02.26354696
Breast cancer over-diagnosis due to mammography screening - A long-term follow-up population study of BreastScreen Norway Harald Weedon-Fekjaer
Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Norway
epidemiology 2026-06-03 Published
medrxiv
10.64898/2026.05.27.26353937
Noninvasive MRD monitoring and profiling of clonal evolution by ctDNA in patients with advanced cancers treated within molecular tumor boards Florian Scherer
Department of Medicine I, Medical Center- University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg,…
oncology 2026-06-03 Published
biorxiv v2
10.64898/2025.12.15.694388
Symbiosis through lysis: host-triggered prophage induction drives probiotic function in Lactiplantibacillus plantarum Renata C. Matos
Institut de Genomique Fonctionnelle de Lyon, Ecole Normale Superieure de Lyon, CNRS UMR 5242, Universite Claude Bernard …
microbiology 2026-06-03 Published
medrxiv
10.64898/2026.06.02.26354617
Effects of interdisciplinary early developmental intervention programs on behavior, executive functioning and participation in children born preterm: A systematic review with meta-analysis Juliane Spiegler
Department of Pediatrics, University Hospital Wuerzburg, Wuerzburg, Germany
pediatrics 2026-06-03 Published
medrxiv v4
10.1101/2025.08.29.25334740
Unraveling the single cell spatial landscapes of melanoma brain metastases Torben Redmer
Institute of Pathology, Unit of Laboratory Animal Pathology, University of Veterinary Medicine Vienna, Austria
oncology 2026-06-03 Published
medrxiv
10.64898/2026.06.02.26354673
Prevalence and Clinical Determinants of Cognitive Impairment in Diverse Patients with Parkinson's Disease Alastair J Noyce
Centre for Preventive Neurology, Wolfson Institute of Population Health, Queen Mary University of London, United Kingdom…
neurology 2026-06-03 Published
biorxiv
10.64898/2026.06.02.729029
Integrated valorization of glycerol and PET into lipids and PHAs using an engineered Yarrowia lipolytica strain and a Pseudomonas-Comamonas consortium Jorge Barriuso
Department of Biotechnology, Center for Biological Research Margarita Salas, Spanish National Research Council (CIB-CSIC…
synthetic biology 2026-06-03 Published
biorxiv
10.64898/2026.06.03.729743
Comparative Secretome Analysis and Enzyme Cocktail Optimization of Six Fungal Species Under Solid-State and Submerged Fermentation for Lignocellulosic Saccharification of Flax Shives Egon Heuson
Univ. Lille, CNRS, Centrale Lille, Univ. Artois, UMR 8181-UCCS-Unite de Catalyse et Chimie du Solide, F-59000 Lille, Fra…
microbiology 2026-06-03 Published
biorxiv v2
10.64898/2026.01.09.698553
Optimizing photoautotrophic production of soluble 3-hydroxybutyrate in Synechocystis sp. PCC 6803 through combinatorial translational tuning Pauli Kallio
Molecular Plant Biology, Department of Life Technologies, University of Turku, FI-20014 Turku, Finland
synthetic biology 2026-06-03 Published
medrxiv v2
10.64898/2026.04.22.26351552
Targeted memory reactivation during sleep modulates spindle and slow wave density, but not motor memory consolidation, in Parkinson's disease Moran Gilat
KU Leuven, Department of Rehabilitation Sciences, Neurorehabilitation Research Group (eNRGy), Leuven, Belgium
neurology 2026-06-02 Published
biorxiv
10.64898/2026.06.01.729239
Multihospital expansion of vancomycin-resistant Enterococcus faecium ST117-CT7799 and transmission of linear plasmids co-carrying vanA and linezolid resistance genes, Comunitat Valenciana, Spain (2022-2024) Fernando Gonzalez-Candelas
Joint Research Unit Infection and Public Health FISABIO-Univ. Valencia, Institute for Integrative Systems Biology (I2Sys…
microbiology 2026-06-02 Published